Systems and Network Medicine redefine medicine by revolutionising our understanding and classification of diseases, i.e. no longer by organ or symptom, but by underlying molecular mechanism. By this Systems and Network Medicine will enable Precision Medicine, i.e. precision diagnosis and precision therapy to cure and ideally prevent disease. Systems and Network Medicine achieve this by highly interdisciplinary research by clinical scientists, translational biomedical scientists, applied bioinformaticians, applied mathematicians, etc.